When the Mexican land offices closed in the fall of 1835, Irion returned to the practice of medicine in Nacogdoches. On September 14, 1835, he was elected to the Committee of Safety and Vigilance for Nacogdoches and on April 14, 1836, was a commandant of Nacogdoches Municipality. He was a senator from Nacogdoches in the First Congress of the Republic of Texas, from October 4, 1836, to June 13, 1837. President Sam Houston appointed him secretary of state of the Republic of Texas in 1837, and he traveled to the United States, Canada, England, and Europe until President Mirabeau B. Lamar appointed Barnard E. Bee to succeed him on December 13, 1838.
Irion was a charter member of the Philosophical Society of Texas and an Episcopalian. On March 29 or 30, 1840, he married Anna W. Raguet of Nacogdoches, daughter of Henry Raguet; they had five children. Irion continued the practice of medicine in Nacogdoches until his death, on March 2, 1861. He was buried in Oak Grove Cemetery in Nacogdoches, where a monument was erected in his honor. Irion County in West Texas was named for him in 1889. Source
31° 36.202, -094° 38.945
Oak Grove Cemetery