Samuel Thompson, physician, participant in the Revolutionary War, and alcalde of San Augustine Municipality, Texas, was born in 1765, the son of George Thompson of England. He was a resident of the Spartanburg District of South Carolina when he enlisted for service in the American Revolution in 1778 or 1779, at the age of thirteen or fourteen, under Capt. Joseph Wofford. He was an express carrier and wagoner and fought in the battle of Cowpens. Thompson married Precius Wofford after the war, and the couple owned three slaves. They sailed with other members of the Thompson family to Coahuila and Texas in 1826. Dr. Thompson is listed in Stephen F. Austin's register of families, and the first census of Texas enrolled him as a physician owning eighteen slaves. In 1834 and 1835 Thompson was alcalde in San Augustine. Thompson Academy was founded about 1839. The institution, about seven miles east of San Augustine, was donated by Thompson and named after him. He died in 1843 in San Augustine County and was buried on the original Thompson settlement.