On December 19, 1963, he was acquired by Houston. The Colt .45s' general manager was aware of Bond's illness, but the team doctor examined him and determined that the leukemia was in remission. Bond then turned in his best Major League season as the starting first baseman for the 1964 Colt .45s, leading Houston in home runs and runs batted in, and appearing in 148 games. The following year, Bond held onto his starting job, but his production slumped with the team's move into the Astrodome; some teammates speculated that his leukemia had recurred that season, affecting his play.
Traded to the Twins just before the 1966 season, he returned to Triple-A and batted .316 with 18 home runs in 122 games for the Denver Bears, earning an invitation to spring training for 1967. Bond made the team and batted .313 in part-time duty during the season's first month, but the Twins released him on May 15 Although Bond was snapped up by the Jacksonville Suns, his declining health forced him to the sidelines after only three games. He entered a Houston hospital for cancer treatment, but died there on September 14, 1967 at age 29.
29° 55.791, -095° 27.063
Houston National Cemetery