David Phillip Vetter, known as the “Bubble Boy,” son of Carol Ann (Rizzo) Vetter and David Joseph Vetter, Jr., was born in Houston, Texas, on September 21, 1971. Vetter was born with severe combined immunodeficiency (SCID), an inherited disease that results in a weakened immune system. Immediately after his birth, he was placed in a sterile containment system designed to keep out germs that could risk his life.
Carol Ann and David Vetter, Jr., had two children before David: a healthy girl named Katherine in 1968 and a son named David Joseph Vetter III in 1970. Their first son was born with SCID and died in infancy. After his death, the Vetters received genetic counseling at Texas Children’s Hospital in Houston by pediatric immunologists Mary Ann South and John R. Montgomery. Knowing the risks, the Vetters conceived another boy. The child had a one in two chance of being born with SCID, for which, except for an exact match bone marrow transplant, there was no cure at the time. Raphael Wilson, an experimental biologist, suggested placing the baby in a germ-free environment until a bone marrow transplant could be performed to develop the child’s immune system. South and Montgomery agreed and preparations were made at Texas Children’s Hospital. Seconds after his birth, David Phillip Vetter was placed in a sterile isolator. Doctors quickly confirmed that he had SCID.
It was unclear how long David would need to remain in the isolator. Doctors were initially confident that his isolation might last only weeks or months, and the family had hope that his older sister would be a suitable bone marrow donor, but she was not a match. Bone marrow transplants were still in the early stages, and a donor match was not identified. In the meantime, great effort was taken to isolate David from germs. As he grew, his crib isolator, colloquially known as a “bubble,” was enlarged and a playroom was attached to it. A similar containment system was built at his family home in Montgomery County, Texas, so he could split his time between there and the hospital.
When David Vetter was three years old, Rev. Raymond J. Lawrence, the hospital chaplain, convened an ethics consultation on his case. He cited concerns over David’s indefinite stay in the bubble and suggested that medical personnel were more motivated by the opportunity for medical technological developments than the boy’s own humanity—claims that both David’s medical team and family refuted. Raphael Wilson and John Montgomery shared positive evaluations of David’s development and were optimistic that a cure would be found soon.
Vetter’s family and care team wanted to make his life as normal as possible. He was baptized with sterile holy water and raised Roman Catholic. From an early age, he was taught about the outside world. He received tutoring and completed school from his isolator. A phone was set up inside to facilitate learning. He formed close relationships with hospital staff. In 1977 he was allowed to leave the bubble in a protective space suit specially designed by NASA. His mobility was short-lived as he quickly outgrew the suit. Doctors also observed, however, that the “bubble” resulted in “greatly reduced spatial awareness” for the boy.
Vetter’s case captured public attention. The press referred to him as David and the “Bubble Boy,” and news stories featured life updates, photographs, and interviews with his care team. The press respected the family’s request to withhold their surname to the public—information that was not released until ten years after their son’s death. His physicians published clinical case reports on him. Donations poured in to help the family cover medical expenses.
Medical advances made unmatched bone marrow transplants possible in the early 1980s. On October 21, 1983, under the direction of medical team leader Dr. William Shearer, David received a bone marrow transfusion from his sister in the hopes that it would activate his immune system. In January he became critically ill following the procedure and could not be treated in the isolator. After twelve years of living in isolation, it became medically necessary for David to leave the isolator, which he did in early February. David Vetter died of complications from the bone marrow transplant on February 22, 1984, in Texas Children’s Hospital. Doctors later discovered that the Epstein-Barr virus, at the time undetected in his sister’s bone marrow donation, had introduced lymphoma into his system.
The Allergy and Immunology Clinic at Texas Children’s Hospital subsequently established the David Center with the mission to research, diagnose, and treat immune deficiencies. David’s tissue samples were used for clinical research which, nine years after his death, led to the breakthrough discovery of the gene that caused SCID. In the twenty-first century, with proper diagnosis and treatment, children with SCID have a much higher rate of recovery and survival. Isolators are no longer used. Source
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