He began his political career as a delegate to the Democratic National Convention in 1936 and later as chairman of the Dallas County Democratic Executive Committee (1942-1945). In the 1946 Texas Congressional election, Wilson defeated primary opponent Sarah T. Hughes by 14,000 votes, then defeated Republican L.W. Stayart in the 1946 general election. He was re-elected in 1948, 1950 and 1952, but was not a candidate for renomination in 1954.
He served as district judge of the criminal district court of Texas in 1943 and 1944, being known as Judge J. Frank Wilson. He was appointed judge of Criminal District Court No. 1, Dallas, Texas, in 1955, in which capacity he served until September 1968. During the Jack Ruby trial in Dallas, Wilson was granted a vacation so that his larger courtroom could accommodate Judge Joe B. Brown for the Ruby Trial. Wilson interrupted his vacation to fill in for the ailing Judge Brown. He retired due to illness and died in Dallas, Texas, October 13, 1968.
32° 52.017, -096° 46.734
Sparkman-Hillcrest Memorial Park Cemetery